Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women.

Molecular human reproduction - 1 Aug 2009

Chen Chen, Wickenheisser Jessica, Ewens Kathryn G, Ankener Wendy, Legro Richard S, Dunaif Andrea, McAllister Jan M, Spielman Richard S, Strauss Jerome F

Abstract excerpt

Polycystic ovary syndrome (PCOS) is characterized by excessive theca cell androgen secretion, dependent upon LH, which acts through the intermediacy of 3',5'-cyclic adenosine monophosphate (cAMP). cAMP signaling pathways are controlled through regulation of its synthesis by adenylyl cyclases, and cAMP degradation by phosphodiesterases (PDEs). PDE8A, a high-affinity cAMP-specific PDE is expressed in the ovary and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3',5'-Cyclic-AMP Phosphodiesterases
Share to Androgens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to COS Cells

Share to Dehydroepiandrosterone Sulfate

Share to Polycystic Ovary Syndrome

Share to Sequence Homology, Amino Acid

Share to Testosterone

Source

Open in PubMed Open full text

Identifiers

PMID: 19482904
DOI: 10.1093/molehr/gap035
PMCID: PMC2709315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women.PMID 19482904Read ↗

Functional characteristics and research trends of PDE11A in human diseases (Review).Semantic proximity Read ↗

Clinical and Molecular Genetics of the Phosphodiesterases (PDEs)Semantic proximity Read ↗

PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile.Semantic proximity Read ↗

A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.Semantic proximity Read ↗

Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular CancersSemantic proximity Read ↗

Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer.Semantic proximity Read ↗

Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome.Semantic proximity Read ↗

Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours.Semantic proximity Read ↗

Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population.Semantic proximity Read ↗

Genetic variations in the 3'-untranslated region of SLC18A2 are associated with serum FSH concentration in polycystic ovary syndrome patients and regulate gene expression in vitro.Semantic proximity Read ↗

Genetic alterations within the DENND1A gene in patients with polycystic ovary syndrome (PCOS).Semantic proximity Read ↗

PDE4DIP in health and diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.