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Article

CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney.

The Journal of clinical investigation - 1 Mar 2006

Lu Ming, Leng Qiang, Egan Marie E, Caplan Michael J, Boulpaep Emile L, Giebisch Gerhard H, Hebert Steven C

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel plays vital roles in fluid transport in many epithelia. While CFTR is expressed along the entire nephron, its function in renal tubule epithelial cells remains unclear, as no specific renal phenotype has been identified in cystic fibrosis. CFTR has been proposed as a regulator of the 30 pS, ATP-sensitive renal K channel (Kir1.1, also known...

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Source

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Identifiers

PMID: 16470247
DOI: 10.1172/JCI26961
PMCID: PMC1361349

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney.PMID 16470247Read ↗

Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct.Semantic proximity Read ↗

CFTR null mutation altered cAMP-sensitive and swelling-activated Cl- currents in primary cultures of mouse nephron.Semantic proximity Read ↗

Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia.Semantic proximity Read ↗

How Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).Semantic proximity Read ↗

Dibasic phosphorylation sites in the R domain of CFTR have stimulatory and inhibitory effects on channel activation.Semantic proximity Read ↗

Both the wild type and a functional isoform of CFTR are expressed in kidneySemantic proximity Read ↗

pH-dependent modulation of the cloned renal K+ channel, ROMK.Semantic proximity Read ↗

CFTR regulation of intracellular calcium in normal and cystic fibrosis human airway epithelia.Semantic proximity Read ↗

AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.Semantic proximity Read ↗

Renal proximal tubule function is preserved in Cftr(tm2cam) deltaF508 cystic fibrosis mice.Semantic proximity Read ↗

Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.Semantic proximity Read ↗

Adenosine triphosphate-dependent asymmetry of anion permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.Semantic proximity Read ↗

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