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Article

CFTR regulation of intracellular calcium in normal and cystic fibrosis human airway epithelia.

The Journal of membrane biology - 1 Oct 2000

Walsh D E, Harvey B J, Urbach V

Abstract excerpt

In cystic fibrosis airway epithelia, mutation of the CFTR protein causes a reduced response of Cl(-) secretion to secretagogues acting via cAMP. Using a Ca(2+) imaging system, the hypothesis that CFTR activation may permit ATP release and regulate [Ca(2+)](i) via a receptor-mediated mechanism, is tested in this study. Application of external nucleotides produced a significant increase in [Ca(2+)](i) in normal...

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Source

Identifiers

PMID: 11014859
DOI: 10.1007/s002320010004

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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