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Article

Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct.

Proceedings of the National Academy of Sciences of the United States of America - 30 Mar 2010

Lu Ming, Dong Ke, Egan Marie E, Giebisch Gerhard H, Boulpaep Emile L, Hebert Steven C

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in many segments of the mammalian nephron, where it may interact with and modulate the activity of a variety of apical membrane proteins, including the renal outer medullary potassium (ROMK) K(+) channel. However, the expression of CFTR in apical cell membranes or its function as a Cl(-) channel in native renal epithelia has not been...

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Source

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Identifiers

PMID: 20231442
DOI: 10.1073/pnas.0902661107
PMCID: PMC2851921

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct.PMID 20231442Read ↗

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CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney.Semantic proximity Read ↗

Renal proximal tubule function is preserved in Cftr(tm2cam) deltaF508 cystic fibrosis mice.Semantic proximity Read ↗

Cystic fibrosis transmembrane conductance regulator (CFTR) and renal function.Semantic proximity Read ↗

Both the wild type and a functional isoform of CFTR are expressed in kidneySemantic proximity Read ↗

Chloride channels in the kidney: lessons learned from knockout animalsSemantic proximity Read ↗

CFTR channels in immortalized human airway cellsSemantic proximity Read ↗

CFTR: a hub for kinases and crosstalk of cAMP and Ca2+.Semantic proximity Read ↗

CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partnersSemantic proximity Read ↗

CFTR and Ca2+ signaling in cystic fibrosisSemantic proximity Read ↗

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Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia.Semantic proximity Read ↗

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