Article
Vpr and HIV-1 disease progression: R77Q mutation is associated with long-term control of HIV-1 infection in different groups of patients.
AIDS (London, England) - 28 Feb 2006
Mologni Daniela, Citterio Paola, Menzaghi Barbara, Zanone Poma Barbara, Riva Chiara, Broggini Valentina, Sinicco Alessandro, Milazzo Laura, Adorni Fulvio, Rusconi Stefano, Galli Massimo, Riva Agostino
Abstract excerpt
BACKGROUND: Vpr (viral protein R) is a 96 amino acids soluble protein that is expressed late during viral replication. Recent studies have focused on the role of a mutation at position 77 that might be associated with the condition of long-term non-progression, but data are still controversial. PATIENTS AND METHODS: Fifteen long-term non-progressors (LTNP), 19 therapy-naive HIV-1-infected patients with...
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