Article
HIV VprR77Q mutation does not influence clinical response of individuals initiating highly active antiretroviral therapy.
AIDS research and human retroviruses - 1 Jul 2006
Chui Celia, Cheung Peter K, Brumme Chanson J, Mo Theresa, Brumme Zabrina L, Montaner Julio S G, Badley Andrew D, Harrigan P Richard
Abstract excerpt
VprR77Q has been associated with long-term nonprogressive (LTNP) HIV infection. We wished to investigate the prevalence, clinical correlates, and effect on treatment response of VprR77Q in a cohort of antiretroviral- naïve individuals initiating highly active antiretroviral therapy (HAART). Baseline plasma samples from 728 subjects were genotyped using RT-PCR and direct DNA sequencing. Cox proportional hazards...
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