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Article

The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90.

PloS one - 10 Jun 2009

Tcherepanova Irina, Starr Aijing, Lackford Brad, Adams Melissa D, Routy Jean-Pierre, Boulassel Mohamed Rachid, Calderhead David, Healey Don, Nicolette Charles

Abstract excerpt

BACKGROUND: A hallmark of AIDS progression is a switch of cytokines from Th1 to Th2 in the plasma of patients. IL-12, a critical Th1 cytokine secreted by antigen presenting cells (APCs) is suppressed by Vpr, implicating it as an important virulence factor. We hypothesize that Vpr protein packaged in the virion may be required for disabling APCs of the first infected mucosal tissues. Consistent with this idea are...

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Identifiers

PMID: 19516896
DOI: 10.1371/journal.pone.0005853
PMCID: PMC2689350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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