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Article

The HIV-1 Vpr R77Q mutant alters host apoptotic gene regulation in CD4+ T cells.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Sithole Sidney T, Ramsey Joshua, Call Macey C, Ewool Kenneth K K, Poole Brian D, Pickett Brett E, Berges Bradford K

Abstract excerpt

Introduction: HIV-1 viral protein R (Vpr) is a multifunctional accessory protein that modulates host cellular pathways and contributes to viral pathogenesis. The HIV-1 Vpr R77Q polymorphism is enriched in long-term non-progressors (LTNPs) and has been associated with reduced overall cell death and a shift toward non-inflammatory apoptotic cell death in CD4+ T cells. However, the host mechanisms underlying this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Membrane Potential, Mitochondrial

Share to Proto-Oncogene Proteins c-bcl-2

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 42445854
DOI: 10.3389/fcimb.2026.1830094
PMCID: PMC13357995

Genes

CD4
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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The HIV-1 Vpr R77Q mutant alters host apoptotic gene regulation in CD4+ T cells.PMID 42445854Read ↗

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