Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions.

PloS one - 19 Oct 2009

Jacquot Guillaume, Le Rouzic Erwann, Maidou-Peindara Priscilla, Maizy Marion, Lefrère Jean-Jacques, Daneluzzi Vincent, Monteiro-Filho Carlos M R, Hong Duanping, Planelles Vicente, Morand-Joubert Laurence, Benichou Serge

Abstract excerpt

Although HIV-1 Vpr displays several functions in vitro, limited information exists concerning their relevance during infection. Here, we characterized Vpr variants isolated from a rapid and a long-term non-progressor (LTNP). Interestingly, vpr alleles isolated from longitudinal samples of the LTN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Gene Products, vpr

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Models, Genetic

Share to Protein Binding

Share to Terminal Repeat Sequences

Share to Ubiquitin-Protein Ligases

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 19838296
DOI: 10.1371/journal.pone.0007514
PMCID: PMC2759284

Genes

DCAF1
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19838296-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions.PMID 19838296Read ↗

HIV1-viral protein R (Vpr) mutations: associated phenotypes and relevance for clinical pathologies.Semantic proximity Read ↗

Vpr and HIV-1 disease progression: R77Q mutation is associated with long-term control of HIV-1 infection in different groups of patients.Semantic proximity Read ↗

Functional conservation of HIV-1 Vpr and variability in a mother-child pair of long-term non-progressors.Semantic proximity Read ↗

The HIV-1 Vpr R77Q mutant alters host apoptotic gene regulation in CD4+ T cells.Semantic proximity Read ↗

HIV-1 Vprâ€”a still â€œenigmatic multitaskerâ€Semantic proximity Read ↗

HIV-1 Vpr: A Closer Look at the Multifunctional Protein from the Structural PerspectiveSemantic proximity Read ↗

Genetic characterization of natural variants of Vpu from HIV-1 infected individuals from Northern India and their impact on virus release and cell death.Semantic proximity Read ↗

Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressorSemantic proximity Read ↗

Vpr R36w and R77Q Mutations Alter HIV-1 Replication and Cytotoxicity in T LymphocytesSemantic proximity Read ↗

Gene defects clustered at the C-terminus of the vpr gene of HIV-1 in long-term nonprogressing mother and child pair: in vivo evolution of vpr quasispecies in blood and plasma.Semantic proximity Read ↗

Localization of HIV-1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophagesSemantic proximity Read ↗

Vpr R36W and R77Q Mutations Alter HIV-1 Replication and Cytotoxicity in T LymphocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.