Article
Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis.
The Journal of clinical investigation - 1 May 2003
Lum Julian J, Cohen Oren J, Nie Zilin, Weaver Joel G, Gomez Timothy S, Yao Xiao-Jian, Lynch David, Pilon André A, Hawley Nanci, Kim John E, Chen Zhaoxia, Montpetit Michael, Sanchez-Dardon Jaime, Cohen Eric A, Badley Andrew D
Abstract excerpt
The absence of immune defects that occurs in the syndrome of long-term nonprogressive (LTNP) HIV infection offers insights into the pathophysiology of HIV-induced immune disease. The (H[F/S]RIG)(2) domain of viral protein R (Vpr) induces apoptosis and may contribute to HIV-induced T cell depletion. We demonstrate a higher frequency of R77Q Vpr mutations in patients with LTNP than in patients with progressive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.