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Article

Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2011

Prahlad Veena, Morimoto Richard I

Abstract excerpt

The consequence of chronic protein misfolding is the basis of many human diseases. To combat the deleterious effects of accumulated protein damage, all cells possess robust quality-control systems, specifically molecular chaperones and clearance machineries, that sense and respond to protein misfolding. However, for many protein conformational diseases, it is unclear why this quality-control system does not...

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PMID: 21844355
DOI: 10.1073/pnas.1106557108
PMCID: PMC3161566

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