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Article

Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis.

Development (Cambridge, England) - 1 Mar 2006

Satoh Wataru, Gotoh Takafumi, Tsunematsu Yasuhiko, Aizawa Shinichi, Shimono Akihiko

Abstract excerpt

Regulation of Wnt signaling is essential for embryonic patterning. Sfrps are secreted Wnt antagonists that directly interact with the Wnt ligand to inhibit signaling. Here, we show that Sfrp1 and Sfrp2 are required for anteroposterior (AP) axis elongation and somitogenesis in the thoracic region...

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Identifiers

PMID: 16467359
DOI: 10.1242/dev.02274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16467359-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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