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Article

Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.

Development (Cambridge, England) - 1 Jul 2016

Kuta Anna, Mao Yaopan, Martin Tina, Ferreira de Sousa Catia, Whiting Danielle, Zakaria Sana, Crespo-Enriquez Ivan, Evans Philippa, Balczerski Bartosz, Mankoo Baljinder, Irvine Kenneth D, Francis-West Philippa H

Abstract excerpt

The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental processes in mice and humans, including development of the vertebrae. Based on conservation of function between Drosophila and mammals, Fat4-Dchs1 signalling has been proposed to regulate planar cell polarity (PCP) and activity of the Hippo effectors Yap and Taz, which regulate cell proliferation, survival and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27381226
DOI: 10.1242/dev.131037
PMCID: PMC4958319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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