Article
The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly.
Developmental biology - 1 Nov 2002
Grotewold Lars, Rüther Ulrich
Abstract excerpt
Mouse mutants have been proven to be a valuable system to analyze the molecular network governing vertebrate limb development. In the present study, we report on the molecular and morphological consequences of the Fused toes (Ft) mutation on limb morphogenesis in homozygous embryos. We show that Ft affects all three axes as the mutant limbs display severe distal truncations of skeletal elements as well as an...
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