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Article

Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1999

Heine H, Kirschning C J, Lien E, Monks B G, Rothe M, Golenbock D T

Abstract excerpt

Toll-like receptor (TLR) 2 and TLR4 have been implicated in the responses of cells to LPS (endotoxin). CD14-transfected Chinese hamster ovary (CHO)-K1 fibroblasts (CHO/CD14) are exquisitely sensitive to endotoxin. Sequence analysis of CHO-TLR2, compared with human and mouse TLR2, revealed a single base pair deletion. This frameshift mutation resulted in an alternative stop codon, encoding a protein devoid of...

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Share to CHO Cells
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Share to Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages, Peritoneal

Share to Receptors, Cell Surface

Share to Toll-Like Receptor 2

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Share to Toll-Like Receptors

Source

Identifiers

PMID: 10358136

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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