Article
A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling.
Genes and immunity - 1 Jun 2004
Hamann L, Kumpf O, Müller M, Visintin A, Eckert J, Schlag P M, Schumann R R
Abstract excerpt
MD-2 is an accessory protein of the Toll-like receptor (TLR)-4, necessary for assembling a receptor complex to sense low quantities of lipopolysaccharide in order to subsequently trigger innate immune responses. MD-2 and TLR-4 are expressed on a variety of immunocompetent cells. Mutations within the TLR-4 gene have been shown to attenuate immune responses against lipopolysaccharide in mice. In humans, a TLR-4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.