Article
Each of the two productive T cell receptor alpha-gene rearrangements found in both the A10 and BM 3.3 T cell clones give rise to an alpha chain which can contribute to the constitution of a surface-expressed alpha beta dimer.
International immunology - 1 Jul 1991
Couez D, Malissen M, Buferne M, Schmitt-Verhulst A M, Malissen B
Abstract excerpt
The H-2 Kb specific cytotoxic T cell clone BM3.3 carries two productive TCR alpha gene rearrangements but expresses a single detectable TCR alpha beta chain combination on its surface. However, when separately analyzed by gene transfer, both productive alpha gene rearrangements are translated into alpha chains capable of pairing with the BM3.3 beta chain and of cell surface expression. Similar observations have...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Clone Cells
- DNA
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Mice
- Models, Genetic
- Molecular Sequence Data