A novel type of aberrant T cell receptor alpha-chain gene rearrangement. Implications for allelic exclusion and the V-J recombination process.

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Article

A novel type of aberrant T cell receptor alpha-chain gene rearrangement. Implications for allelic exclusion and the V-J recombination process.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1990

Hue I, Trucy J, McCoy C, Couez D, Malissen B, Malissen M

Abstract excerpt

In the process of analyzing the contribution of nonproductive alpha- and beta-chain gene rearrangements to the allelic exclusion of TCR gene expression, we have found a novel type of aberrant alpha-gene rearrangement. In one alpha-allele of the mouse KB5-C20 T cell clone, a J alpha gene segment h...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Clone Cells
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
H-2 Antigens
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovalbumin

Receptors, Antigen, T-Cell

Receptors, Antigen, T-Cell, alpha-beta

Recombination, Genetic

Restriction Mapping

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 2160502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2160502-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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