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Article

Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes

21 Dec 2012

Abstract excerpt

Cyclin D1b is a splice variant of the cell cycle regulator cyclin D1 and is known to harbor divergent and highly oncogenic functions in human cancer. While cyclin D1b is induced during disease progression in many cancer types, the mechanisms underlying cyclin D1b function remain poorly understood. Herein, cell and human tumor xenograft models of prostate cancer were utilized to resolve the downstream pathways...

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PMID: 23257359
DOI: 10.1172/jci64750

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