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Article

Kinds of mutations induced by aflatoxin B1 in a shuttle vector replicating in human cells transiently expressing cytochrome P4501A2 cDNA.

Molecular carcinogenesis - 1 Jan 1992

Trottier Y, Waithe W I, Anderson A

Abstract excerpt

Transient expression of rat liver cytochrome P450lA2 cDNA was combined with the use of a shuttle vector as a mutational target to determine the frequency and types of mutation caused by the conversion of aflatoxin B1 into genotoxic metabolites within human cells. Ad293 cells were first transfected with p91-lA2, a rat liver P450lA2 cDNA expression vector, or with p91-lA2(i) (a control vector that has the P450 cDNA...

Topics

Aflatoxins
Bacterial Proteins
Base Sequence
Cells, Cultured
Cytochrome P-450 CYP1A2
Cytochrome P-450 Enzyme System
DNA
Dose-Response Relationship, Drug
Genetic Vectors
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Mutation

Oxidoreductases

Plasmids

Transfection

Source

Identifiers

PMID: 1326989
DOI: 10.1002/mc.2940060209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1326989-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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