Article
Dose-dependent carcinogenicity and frequent Ki-ras proto-oncogene activation by dietary N-nitrosodiethylamine in rainbow trout.
Fundamental and applied toxicology : official journal of the Society of Toxicology - 1 Jul 1994
Hendricks J D, Cheng R, Shelton D W, Pereira C B, Bailey G S
Abstract excerpt
While the experimental data upon which current concepts in mechanistically based risk assessment and molecular epidemiology are grounded derive almost entirely from rodent models, fish models have several attributes (e.g., low background incidence, extremely low cost tumor studies, nonmammalian c...
Topics
- Animals
- Carcinogenicity Tests
- Diethylnitrosamine
- Dose-Response Relationship, Drug
- Female
- Gene Expression Regulation
- Genes, ras
- Liver Neoplasms, Experimental
- Male
- Mutation
- Oncorhynchus mykiss
- Proto-Oncogene Mas
- Sex Factors