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Article

Rapid c-myc mRNA degradation does not require (A + U)-rich sequences or complete translation of the mRNA.

Nucleic acids research - 11 May 1991

Laird-Offringa I A, Elfferich P, van der Eb A J

Abstract excerpt

The c-myc proto-oncogene encodes a highly unstable mRNA. Stabilized, truncated myc transcripts have been found in several human and murine tumors of hematopoietic origin. Recently, two tumors expressing 3' truncated c-myc mRNAs that were five times more stable than normal myc transcripts, were described. We have tried to determine the cause of the increased stability of the 3' truncated myc transcripts by...

Topics

Adenine
Animals
Base Composition
Cells, Cultured
Codon
Guanine
Half-Life
Humans
Mutation
Protein Biosynthesis
Proto-Oncogene Mas
Proto-Oncogene Proteins c-myc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Rats

Restriction Mapping

Simian virus 40

Source

Open in PubMed Open full text

Identifiers

PMID: 1645870
DOI: 10.1093/nar/19.9.2387
PMCID: PMC329447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1645870-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Rapid c-myc mRNA degradation does not require (A + U)-rich sequences or complete translation of the mRNA.PMID 1645870Read ↗

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