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Article

Rapid c-myc mRNA degradation does not require (A + U)-rich sequences or complete translation of the mRNA.

Nucleic acids research - 11 May 1991

Laird-Offringa I A, Elfferich P, van der Eb A J

Abstract excerpt

The c-myc proto-oncogene encodes a highly unstable mRNA. Stabilized, truncated myc transcripts have been found in several human and murine tumors of hematopoietic origin. Recently, two tumors expressing 3' truncated c-myc mRNAs that were five times more stable than normal myc transcripts, were described. We have tried to determine the cause of the increased stability of the 3' truncated myc transcripts by...

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Identifiers

PMID: 1645870
DOI: 10.1093/nar/19.9.2387
PMCID: PMC329447

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