Article
Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function.
Molecular and cellular biology - 1 Jan 1994
Chen C Y, Chen T M, Shyu A B
Abstract excerpt
AU-rich elements (ARE) in the 3' untranslated region of many highly labile mRNAs for proto-oncogenes, lymphokines, and cytokines can act as an RNA-destabilizing element. The absence of a clear understanding of the key sequence and structural features of the ARE that are required for its destabili...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Genes, fos
- Half-Life
- Humans
- Mice
- Models, Biological
- Molecular Sequence Data
- Mutation
- Poly A
- RNA, Messenger