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Article

Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function.

Molecular and cellular biology - 1 Jan 1994

Chen C Y, Chen T M, Shyu A B

Abstract excerpt

AU-rich elements (ARE) in the 3' untranslated region of many highly labile mRNAs for proto-oncogenes, lymphokines, and cytokines can act as an RNA-destabilizing element. The absence of a clear understanding of the key sequence and structural features of the ARE that are required for its destabilizing function has precluded the further elucidation of its mode of action and the basis of its specificity. Combining...

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Identifiers

PMID: 7903419
DOI: 10.1128/mcb.14.1.416-426.1994
PMCID: PMC358391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function.PMID 7903419Read ↗

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.Semantic proximity Read ↗

Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elementsSemantic proximity Read ↗

Heterogeneity in Control of mRNA Stability by AU-rich ElementsSemantic proximity Read ↗

Sequence variations affecting AU-rich element function and disease.Semantic proximity Read ↗

AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation.Semantic proximity Read ↗

Massively Parallel Analysis of Human 3′ UTRs Reveals that AU-Rich Element Length and Registration Predict mRNA DestabilizationSemantic proximity Read ↗

5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants.Semantic proximity Read ↗

A hairpin-like structure within an AU-rich mRNA-destabilizing element regulates trans-factor binding selectivity and mRNA decay kinetics.Semantic proximity Read ↗

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements.Semantic proximity Read ↗

Upf1/Upf2 regulation of 3' untranslated region splice variants of AUF1 links nonsense-mediated and A+U-rich element-mediated mRNA decay.Semantic proximity Read ↗

ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins.Semantic proximity Read ↗

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.Semantic proximity Read ↗

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