Article
Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.
Genes & development - 1 Oct 1992
Savant-Bhonsale S, Cleveland D W
Abstract excerpt
Many short-lived mRNAs, including those encoding lymphokines, cytokines, and proto-oncogenes, contain an AU-rich sequence in their 3'-untranslated regions. These AU domains and, more specifically, AUUUA motifs within them, are widely thought to mediate the extreme instability of the corresponding mRNAs. This is most clearly true for granulocyte monocyte colony stimulating factor (GM-CSF) mRNA whose AUUUA motifs...
Topics
- Animals
- Base Sequence
- Cations, Divalent
- Cell Line, Transformed
- Cricetinae
- DNA
- Globins
- Granulocyte-Macrophage Colony-Stimulating Factor
- Molecular Sequence Data
- Phenotype
- Protein Biosynthesis