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Article

5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants.

Nucleic acids research - 11 Nov 1992

Roy N, Laflamme G, Raymond V

Abstract excerpt

One major determinant of rapid mRNA decay is the presence of AU-rich sequences located in 3' untranslated regions (UTR). To assess for the contribution of upstream sequences on the activity of the 3' AU-rich destabilizing element, we have determined the decay-rates of v-/c-fos hybrid transcripts by quantitative RNA protection analysis. In a transient expression assay, v-/c-fos recombinants generated two mRNA...

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Identifiers

PMID: 1454537
DOI: 10.1093/nar/20.21.5753
PMCID: PMC334413

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