5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants.

doi:10.1093/nar/20.21.5753

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Article

5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants.

Nucleic acids research - 11 Nov 1992

Roy N, Laflamme G, Raymond V

Abstract excerpt

One major determinant of rapid mRNA decay is the presence of AU-rich sequences located in 3' untranslated regions (UTR). To assess for the contribution of upstream sequences on the activity of the 3' AU-rich destabilizing element, we have determined the decay-rates of v-/c-fos hybrid transcripts by quantitative RNA protection analysis. In a transient expression assay, v-/c-fos recombinants generated two mRNA...

Topics

3T3 Cells
Animals
Base Composition
Base Sequence
Cell Transformation, Neoplastic
Cloning, Molecular
DNA
Globins
Humans
Introns
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Proteins v-fos

Proto-Oncogene Proteins c-fos

RNA Processing, Post-Transcriptional

RNA, Messenger

Recombinant Fusion Proteins

Source

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Identifiers

PMID: 1454537
DOI: 10.1093/nar/20.21.5753
PMCID: PMC334413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1454537-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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