Article
Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins.
The Journal of biological chemistry - 18 Feb 1994
Henics T, Sanfridson A, Hamilton B J, Nagy E, Rigby W F
Abstract excerpt
The MLA 144 gibbon T cell line is infected with a type C retrovirus and constitutively expresses interleukin-2 (IL-2) and granulocyte macrophage colony-stimulating factor (GM-CSF). IL-2 mRNA levels are 10-fold more abundant than GM-CSF in these cells. Comparable transcriptional rates for these ly...
Topics
- Alleles
- Animals
- Base Sequence
- Blotting, Northern
- Cell Line
- Cell Nucleus
- Cytoplasm
- Dactinomycin
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Hylobates
- Interleukin-2
- Molecular Sequence Data
- RNA Probes
- RNA Processing, Post-Transcriptional
- RNA, Messenger
- RNA-Binding Proteins
- Repetitive Sequences, Nucleic Acid