Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

doi:10.1101/gad.5.2.221

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Article

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

Genes & development - 1 Feb 1991

Shyu A B, Belasco J G, Greenberg M E

Abstract excerpt

The mechanisms by which c-fos mRNA is targeted for decay have been examined. Rapid removal of the poly(A) tail occurs before the transcribed portion of the c-fos message is degraded. Identification of the determinants that mediate c-fos message deadenylation reveals that they coincide directly wi...

Topics

Animals
Base Sequence
Cell Line
Globins
Kinetics
Mice
Molecular Sequence Data
Mutation
Poly A
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-fos
Proto-Oncogenes
RNA, Messenger
Rabbits

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