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Article

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

Genes & development - 1 Feb 1991

Shyu A B, Belasco J G, Greenberg M E

Abstract excerpt

The mechanisms by which c-fos mRNA is targeted for decay have been examined. Rapid removal of the poly(A) tail occurs before the transcribed portion of the c-fos message is degraded. Identification of the determinants that mediate c-fos message deadenylation reveals that they coincide directly with previously characterized determinants of c-fos mRNA instability, one in the protein-coding region and the other an...

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PMID: 1899842
DOI: 10.1101/gad.5.2.221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.PMID 1899842Read ↗

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