Article
Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.
Journal of virology - 1 Jul 1991
Martínez M A, Carrillo C, González-Candelas F, Moya A, Domingo E, Sobrino F
Abstract excerpt
We document the rapid alteration of fitness of two foot-and-mouth disease virus (FMDV) mutants resistant to a neutralizing monoclonal antibody. Both mutants showed a selective disadvantage in BHK-21 cells when passaged in competition with their parental FMDV. Upon repeated replication of the mutants alone, they acquired a selective advantage over the parental FMDV and fixed additional genomic substitutions...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Aphthovirus
- Base Sequence
- Biological Evolution
- Cell Line
- Cricetinae
- In Vitro Techniques
- Molecular Sequence Data
- Mutation