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Article

Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.

Journal of virology - 1 Jul 1991

Martínez M A, Carrillo C, González-Candelas F, Moya A, Domingo E, Sobrino F

Abstract excerpt

We document the rapid alteration of fitness of two foot-and-mouth disease virus (FMDV) mutants resistant to a neutralizing monoclonal antibody. Both mutants showed a selective disadvantage in BHK-21 cells when passaged in competition with their parental FMDV. Upon repeated replication of the mutants alone, they acquired a selective advantage over the parental FMDV and fixed additional genomic substitutions...

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Identifiers

PMID: 1645804
DOI: 10.1128/JVI.65.7.3954-3957.1991
PMCID: PMC241436

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