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Article

Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses.

Journal of virology - 1 Jun 1991

Holland J J, de la Torre J C, Clarke D K, Duarte E

Abstract excerpt

We describe a sensitive, internally controlled method for comparing the genetic adaptability and relative fitness of virus populations in constant or changing host environments. Certain monoclonal antibody-resistant mutants of vesicular stomatitis virus can compete equally during serial passages in mixtures with the parental wild-type clone from which they were derived. These genetically marked "surrogate...

Topics

Animals
Antibodies, Monoclonal
Binding, Competitive
Cell Line
Cloning, Molecular
Genetic Variation
Humans
Mutation
RNA Viruses
Sensitivity and Specificity
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2033662
DOI: 10.1128/JVI.65.6.2960-2967.1991
PMCID: PMC240937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2033662-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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