Influence of the mutant spectrum in viral evolution: focused selection of antigenic variants in a reconstructed viral quasispecies.

Abstract excerpt

RNA viruses replicate as complex mutant distributions termed viral quasispecies. Despite this, studies on virus populations subjected to positive selection have generally been performed and analyzed as if the viral population consisted of a defined genomic nucleotide sequence; such a simplification may not reflect accurately the molecular events underlying the selection process. In the present study, we have...

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