Article
In vivo analysis of the stability and fitness of variants recovered from foot-and-mouth disease virus quasispecies.
The Journal of general virology - 1 Jul 1998
Carrillo C, Borca M, Moore D M, Morgan D O, Sobrino F
Abstract excerpt
We have analysed the ability to infect pigs of two foot-and-mouth disease virus (FMDV) variants isolated at low frequencies from virus populations (quasispecies) generated in pigs on infection with a parental virus, C-S8c1. A monoclonal antibody-resistant mutant (MARM21), and a variant isolated at early times post-infection (S-3T1), each exhibiting a unique amino acid substitution in VP1, were able to cause...
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