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Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia – An <b><i>in vivo</i></b> study

3 Feb 2006

Abstract excerpt

Intrinsic or acquired resistance to vincristine (VCR), an antimicrotubule agent used in the treatment of childhood acute lymphoblastic leukemia (ALL), is a major clinical problem. Using a clinically relevant NOD/SCID mouse xenograft model of ALL, we established that alterations in the actin and tubulin cytoskeleton are involved in in vivo VCR resistance. Altered protein expression between VCR-sensitive ALL...

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PMID: 16456880
DOI: 10.1002/pmic.200500417

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