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Article

Quantitative interactome analysis reveals a chemoresistant edgotype.

Nature communications - 3 Aug 2015

Chavez Juan D, Schweppe Devin K, Eng Jimmy K, Zheng Chunxiang, Taipale Alex, Zhang Yiyi, Takara Kohji, Bruce James E

Abstract excerpt

Chemoresistance is a common mode of therapy failure for many cancers. Tumours develop resistance to chemotherapeutics through a variety of mechanisms, with proteins serving pivotal roles. Changes in protein conformations and interactions affect the cellular response to environmental conditions contributing to the development of new phenotypes. The ability to understand how protein interaction networks adapt to...

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Share to DNA Topoisomerases, Type II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26235782
DOI: 10.1038/ncomms8928
PMCID: PMC4532879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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