Article

Differential gene expression analysis by RNA-seq reveals the importance of actin cytoskeletal proteins in leukemia cells

2017-01-18

Abstract excerpt

Development of drug resistance limits the effectiveness of anticancer treatments. Understanding the molecular mechanisms triggering this event in tumor cells may lead to improved therapeutic strategies. Here we used RNA-seq to compare the transcriptomes of an erythroleukemia progenitor cell line (MEL-DS19) and a derived cell line with induced resistance to differentiation (MEL-R). RNA-seq analysis identified a tot...

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Literature Corpus work: c7a5ec2c-7a88-56e6-aad7-e19b72417fa7
DOI: 10.7287/peerj.preprints.2731v1

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