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Class III β‐tubulin and the cytoskeletal gateway for drug resistance in ovarian cancer

25 Apr 2011

Abstract excerpt

The Class III β-tubulin isotype (βIII-tubulin) is a predictive biomarker in ovarian cancer and other solid tumor malignancies. We discovered that βIII-tubulin function is linked to two GTPases: guanylate-binding protein 1 (GBP1), which activates its function, and GNAI1, which inhibits it. This finding was demonstrated in a panel of ovarian cancer cells resistant to several chemotherapeutic agents. Using a protein...

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PMID: 21520077
DOI: 10.1002/jcp.22813

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