Article

A first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity in hematological cancers

2022-11-25

Abstract excerpt

Hematological cancers are among the most common cancers in adults and in children. Despite significant improvements in therapies, many patients still succumb to the disease, therefore, novel therapies are needed. The Wiskott-Aldrich syndrome protein (WASp) family proteins regulate actin assembly in conjunction with the Arp2/3 complex, a ubiquitous nucleation factor. WASp is expressed exclusively in hematopoietic c...

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Literature Corpus work: 65f20ff9-b23e-5f70-b72e-3e9a4fd6e97b
DOI: 10.1101/2022.11.25.517686

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