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Article

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

15 Mar 2021

Abstract excerpt

BACKGROUND: Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein maturation by proteolytic processing in 11 pediatric B- and T- cell ALL patients and 19 corresponding xenografts. METHODS: Xenograft models were generated for each pediatric...

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PMID: 33722259
DOI: 10.1186/s13046-021-01835-8

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