Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.

Cancer research - 1 Aug 2001

Kavallaris M, Tait A S, Walsh B J, He L, Horwitz S B, Norris M D, Haber M

Abstract excerpt

Vinca alkaloids are used extensively in the treatment of childhood acute lymphoblastic leukemia (ALL) and despite their usefulness, drug resistance remains a serious clinical problem. Vinca alkaloids bind to the beta-tubulin subunit of the alpha/beta-tubulin heterodimer and inhibit polymerization...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Phytogenic
Share to Electrophoresis, Gel, Two-Dimensional
Share to Leukemia-Lymphoma, Adult T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubule-Associated Proteins

Share to Microtubules

Share to Tubulin

Share to Vinblastine

Share to Vincristine

Source

Identifiers

PMID: 11479219

Genes

MAP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11479219-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells.PMID 11479219Read ↗

Neuronal-associated microtubule proteins class III beta-tubulin and MAP2c in neuroblastoma: role in resistance to microtubule-targeted drugs.Semantic proximity Read ↗

Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia.Semantic proximity Read ↗

Cancer cells acquire mitotic drug resistance properties through beta I-tubulin mutations and alterations in the expression of beta-tubulin isotypes.Semantic proximity Read ↗

Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia – An <b><i>in vivo</i></b> studySemantic proximity Read ↗

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistanceSemantic proximity Read ↗

Class I beta-tubulin mutations in 2-methoxyestradiol-resistant acute lymphoblastic leukemia cells: implications for drug-target interactions.Semantic proximity Read ↗

Microtubules: A dynamic target in cancer therapySemantic proximity Read ↗

Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions.Semantic proximity Read ↗

Mutations in alpha- and beta-tubulin that stabilize microtubules and confer resistance to colcemid and vinblastine.Semantic proximity Read ↗

Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization.Semantic proximity Read ↗

Microtubule alterations and resistance to tubulin-binding agents (Review)Semantic proximity Read ↗

Hematologic β-tubulin VI isoform exhibits genetic variability that influences paclitaxel toxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.