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Article

Identification of chemoresistance-related cell-surface glycoproteins in leukemia cells and functional validation of candidate glycoproteins.

Journal of proteome research - 7 Mar 2014

Sun Zhen, Dong Jiaqiang, Zhang Song, Hu Zhengyan, Cheng Kai, Li Kai, Xu Bo, Ye Mingliang, Nie Yongzhan, Fan Daiming, Zou Hanfa

Abstract excerpt

Chemoresistance remains the most significant obstacle to successful chemotherapy for leukemia, and its exact mechanism is still unknown. In this work, we used the cell-surface capturing method together with quantitative proteomics to investigate differences in the glycoproteomes of adriamycin-sensitive and adriamycin-resistant leukemia cells. Two quantitative methods, isotopic dimethyl labeling and SWATH, were...

Read the complete abstract on PubMed

Topics

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Share to Antibiotics, Antineoplastic
Share to Cathepsin D

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, Liquid

Share to Doxorubicin

Share to Gene Expression Regulation, Leukemic

Share to Glucose Transporter Type 1

Share to Staining and Labeling

Share to Tacrolimus Binding Proteins

Source

Identifiers

PMID: 24467213
DOI: 10.1021/pr4010822

Genes

ABCB1
CTSD
FKBP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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