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Article

The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus.

The Journal of biological chemistry - 5 Jun 1991

Myers M G, Backer J M, Siddle K, White M F

Abstract excerpt

We studied the structure and function of the human insulin receptor (IR) and a mutant which lacked the last 43 amino acids of the beta-subunit (IR delta ct). This deletion removed tyrosine (Tyr1322, Tyr1316) and threonine (Thr1336) phosphorylation sites. In Chinese hamster ovary (CHO) cells, insulin binding to the mutant receptor was normal, and [35S]methionine labeling indicated that both the IR and IR delta ct...

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PMID: 1645354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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