The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus.

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Article

The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus.

The Journal of biological chemistry - 5 Jun 1991

Myers M G, Backer J M, Siddle K, White M F

Abstract excerpt

We studied the structure and function of the human insulin receptor (IR) and a mutant which lacked the last 43 amino acids of the beta-subunit (IR delta ct). This deletion removed tyrosine (Tyr1322, Tyr1316) and threonine (Thr1336) phosphorylation sites. In Chinese hamster ovary (CHO) cells, insulin binding to the mutant receptor was normal, and [35S]methionine labeling indicated that both the IR and IR delta ct...

Topics

1-Phosphatidylinositol 4-Kinase
Animals
Autoradiography
Chromatography, High Pressure Liquid
Cricetinae
Cricetulus
Electrophoresis, Polyacrylamide Gel
Female
Glycogen
Humans
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovary

Peptide Mapping

Phosphorylation

Phosphotransferases

Receptor, Insulin

Thymidine

Trypsin

Source

Open in PubMed

Identifiers

PMID: 1645354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1645354-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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