Article
Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.
Molecular and cellular biology - 1 Sept 1995
Chen D, Van Horn D J, White M F, Backer J M
Abstract excerpt
Insulin signals are mediated through tyrosine phosphorylation of specific proteins such as insulin receptor substrate 1 (IRS-1) and Shc by the activated insulin receptor (IR). Phosphorylation of both proteins is nearly abolished by an alanine substitution at Tyr-960 (A960) in the beta-subunit of...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- CHO Cells
- Calcium-Calmodulin-Dependent Protein Kinases
- Cricetinae
- DNA
- Dose-Response Relationship, Drug
- GRB2 Adaptor Protein
- Glycogen
- Insulin
- Insulin Receptor Substrate Proteins
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases