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Article

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990

Wilden P A, Backer J M, Kahn C R, Cahill D A, Schroeder G J, White M F

Abstract excerpt

We have studied the function of a mutant insulin receptor (IR) molecule in which Tyr-1146, one of the first autophosphorylation sites in the beta subunit, was replaced with phenylalanine (IRF1146). Autophosphorylation of the partially purified IRF1146 was reduced 60-70% when compared to the wild-type IR but was still stimulated by insulin. The phosphotransferase activity of the dephospho form of both the IR and...

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Identifiers

PMID: 2159147
DOI: 10.1073/pnas.87.9.3358
PMCID: PMC53899

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