The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

doi:10.1073/pnas.87.9.3358

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Article

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990

Wilden P A, Backer J M, Kahn C R, Cahill D A, Schroeder G J, White M F

Abstract excerpt

We have studied the function of a mutant insulin receptor (IR) molecule in which Tyr-1146, one of the first autophosphorylation sites in the beta subunit, was replaced with phenylalanine (IRF1146). Autophosphorylation of the partially purified IRF1146 was reduced 60-70% when compared to the wild-...

Topics

Animals
Base Sequence
Cell Division
Cell Line
DNA Replication
Glycogen Synthase
Insulin
Kinetics
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Phenylalanine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Plasmids

Protein-Tyrosine Kinases

Receptor, Insulin

Signal Transduction

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2159147
DOI: 10.1073/pnas.87.9.3358
PMCID: PMC53899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2159147-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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