Article
Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: comparison of receptors expressed in CHO and NIH-3T3 cells.
Biochimica et biophysica acta - 16 Dec 1993
Levy-Toledano R, Accili D, Taylor S I
Abstract excerpt
We have studied the structure and the function of a truncated human insulin receptor in which 113 amino acids (aa 1231-1343) at the C-terminus of the beta-subunit were deleted. In this study, wild-type and truncated insulin receptors were expressed by stable transfection in NIH-3T3 cells and CHO...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cloning, Molecular
- Cricetinae
- DNA
- Endocytosis
- Gene Expression
- Humans
- Insulin
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Phosphorylation
- Protein Processing, Post-Translational