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Article

The carboxyl terminal extension of the Drosophila insulin receptor homologue binds IRS-1 and influences cell survival.

The Journal of biological chemistry - 27 Aug 1999

Marin-Hincapie M, Garofalo R S

Abstract excerpt

The Drosophila insulin receptor (INR) homolog includes an extension of approximately 400 amino acids at the carboxyl-terminal end of its beta subunit containing several tyrosine-based motifs known to mediate interactions with signaling proteins. In order to explore the role of this extension in INR function, mammalian expression vectors encoding either the complete INR beta subunit (beta-Myc) or the INR beta...

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Identifiers

PMID: 10455177
DOI: 10.1074/jbc.274.35.24987

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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