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Article

Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform.

Molecular and cellular biology - 1 Nov 2005

Wong Adrianne, Bogni Silvia, Kotka Pille, de Graaff Esther, D'Agati Vivette, Costantini Frank, Pachnis Vassilis

Abstract excerpt

The receptor tyrosine kinase Ret plays a critical role in the development of the mammalian excretory and enteric nervous systems. Differential splicing of the primary Ret transcript results in the generation of two main isoforms, Ret9 and Ret51, whose C-terminal amino acid tails diverge after tyr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16227613
DOI: 10.1128/MCB.25.21.9661-9673.2005
PMCID: PMC1265823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16227613-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform.PMID 16227613Read ↗

Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in miceSemantic proximity Read ↗

Critical and distinct roles for key RET tyrosine docking sites in renal development.Semantic proximity Read ↗

A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia.Semantic proximity Read ↗

Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice.Semantic proximity Read ↗

Loss of Sprouty1 rescues renal agenesis caused by Ret mutation.Semantic proximity Read ↗

A Single RET Mutation in Hirschsprung Disease Induces Intestinal Aganglionosis Via a Dominant-Negative Mechanism.Semantic proximity Read ↗

Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice.Semantic proximity Read ↗

Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.Semantic proximity Read ↗

RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release from Enteroendocrine CellsSemantic proximity Read ↗

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.Semantic proximity Read ↗

Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epitheliaSemantic proximity Read ↗

Multiple functional effects of RET kinase domain sequence variants in Hirschsprung disease.Semantic proximity Read ↗

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