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Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia.

American journal of physiology. Renal physiology - 1 Nov 2009

Sims-Lucas Sunder, Cullen-McEwen Luise, Eswarakumar Veraragavan P, Hains David, Kish Kayle, Becknell Brian, Zhang Jue, Bertram John F, Wang Fen, Bates Carlton M

Abstract excerpt

Fibroblast growth factor receptor 2 (Fgfr2) signaling is critical in maintaining ureteric branching architecture and mesenchymal stromal morphogenesis in the kidney. Fibroblast growth factor receptor substrate 2alpha (Frs2alpha) is a major docking protein for Fgfr2 with downstream targets including Ets variant (Etv) 4 and Etv5 in other systems. Furthermore, global deletion of Frs2alpha causes early embryonic...

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Cell Count
Epithelium
Fibroblast Growth Factor 2
In Situ Nick-End Labeling
Kidney Diseases

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Organ Culture Techniques

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PMID: 19741018
DOI: 10.1152/ajprenal.00262.2009
PMCID: PMC2781346

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