Article
A dominant negative mutation uncovers cooperative control of caudal Wolffian duct development by Sprouty genes.
Cellular and molecular life sciences : CMLS - 13 Sept 2022
Altés Gisela, Vaquero Marta, Cuesta Sara, Anerillas Carlos, Macià Anna, Espinet Carme, Ribera Joan, Bellusci Saverio, Klein Ophir D, Yeramian Andree, Dolcet Xavi, Egea Joaquim, Encinas Mario
Abstract excerpt
The Wolffian ducts (WD) are paired epithelial tubules central to the development of the mammalian genitourinary tract. Outgrowths from the WD known as the ureteric buds (UB) generate the collecting ducts of the kidney. Later during development, the caudal portion of the WD will form the vas deferens, epididymis and seminal vesicle in males, and will degenerate in females. While the genetic pathways controlling...
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