Article
A comparison of five methods for selecting tagging single-nucleotide polymorphisms.
BMC genetics - 30 Dec 2005
Burkett Kelly M, Ghadessi Mercedeh, McNeney Brad, Graham Jinko, Daley Denise
Abstract excerpt
Our goal was to compare methods for tagging single-nucleotide polymorphisms (tagSNPs) with respect to the power to detect disease association under differing haplotype-disease association models. We were also interested in the effect that SNP selection samples, consisting of either cases, controls, or a mixture, would have on power. We investigated five previously described algorithms for choosing tagSNPS: two...
Topics
- Genetic Techniques
- Humans
- Polymorphism, Single Nucleotide
- Reproducibility of Results