Comparisons of multi-marker association methods to detect association between a candidate region and disease.

Abstract excerpt

The joint use of information from multiple markers may be more effective to reveal association between a genomic region and a trait than single marker analysis. In this article, we compare the performance of seven multi-marker methods. These methods include (1) single marker analysis (either the best-scoring single nucleotide polymorphism in a candidate region or a combined test based on Fisher's method); (2)...

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