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Article

Modeling the effect of an associated single-nucleotide polymorphism in linkage studies.

BMC genetics - 30 Dec 2005

Houwing-Duistermaat Jeanine J, Uh Hae-Won, Lebrec Jeremie J P, Putter Hein, Hsu Li

Abstract excerpt

For linkage analysis in affected sibling pairs, we propose a regression model to incorporate information from a disease-associated single-nucleotide polymorphism located under the linkage peak. This model can be used to study if the associated single-nucleotide polymorphism marker partly explains the original linkage peak. Two sources of information are used for performing this task, namely the genotypes of the...

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PMID: 16451657
DOI: 10.1186/1471-2156-6-S1-S46
PMCID: PMC1866738

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