Article
Modeling the effect of an associated single-nucleotide polymorphism in linkage studies.
BMC genetics - 30 Dec 2005
Houwing-Duistermaat Jeanine J, Uh Hae-Won, Lebrec Jeremie J P, Putter Hein, Hsu Li
Abstract excerpt
For linkage analysis in affected sibling pairs, we propose a regression model to incorporate information from a disease-associated single-nucleotide polymorphism located under the linkage peak. This model can be used to study if the associated single-nucleotide polymorphism marker partly explains the original linkage peak. Two sources of information are used for performing this task, namely the genotypes of the...
Topics
- Chromosomes, Human, Pair 3
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Lod Score
- Microsatellite Repeats
- Models, Genetic
- Polymorphism, Single Nucleotide